Principal Scientist, Protein Sciences
Treeline Biosciences was founded by an experienced team of biopharmaceutical scientists and executives committed to developing new medicines against compelling molecular targets in oncology that have proven difficult to drug. We are pursuing a uniquely integrated approach that applies emerging scientific tools and a commitment to building our lead discovery and computational design infrastructure. As a member of the Protein Sciences team, you will play an integral role supporting early-stage discovery programs by collaborating closely with a cross-functional team of scientists to impact small molecule drug discovery. In this role, you will report to the head of protein sciences and oversee protein science activities at our Watertown site. Specifically, you will impact the target enabling strategy and design and implement gene-to-protein workflows to deliver high-quality protein for use in SAR enabling assays and structural biology efforts.
Responsibilities
- Establish and implement strategies for enabling multiple protein targets.
- Design, express, and purify protein targets to support structural biology and small molecule drug discovery efforts.
- Manage and mentor PhD level Protein Scientists.
- Perform functional and biophysical characterization of proteins using novel and established technical methods.
- Explore and evaluate new technologies related to Protein Science.
- Analyze, interpret, and document data using an ELN and application specific software tools.
- Collaborate across lead discovery, medicine design, and medicinal chemistry teams to efficiently drive projects forward.
Required Qualifications
- PhD in Biochemistry, Biophysics, Structural Biology or related discipline with 2-3 years of relevant postdoctoral training.
- 6+ years of experience in biotech/pharma industry with a track record of producing difficult proteins for small molecule drug discovery projects. Relevant industry experience is a requirement for this role.
- Experience and track record for managing PhD level scientists. Management experience is a requirement for this role.
- Strong candidates will have a track record working with challenging protein targets and/or multi-protein complexes to enable hit finding assay development.
- Proven hands-on experience with multiple expression platforms (e.g., bacteria, insect cell, mammalian cell).
- Proficiency with AKTA instrumentation and a broad range of standard and unique purification and protein QC techniques.
- Protein characterization techniques, such as SDS-PAGE, Western Blot and analytical SEC are required.
- Candidates must possess excellent collaborative skills, demonstrate strong analytical and organizational skills, and work effectively under deadlines.
- Excellent communication skills and the ability to report and present data to colleagues and senior leadership.
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