C2N Diagnostics, a St. Louis based biotechnology company focused on discovering therapeutics and diagnostics for neurodegenerative conditions, is looking for an Analytical Mass Spectrometry Scientist.
C2N Diagnostics focuses its therapeutic discovery and development efforts around mechanism-based approaches to prevent or stop the progression of human neurological disorders. Its diagnostic efforts revolve around bringing accurate, widely accessible, and cost-effective blood tests to the clinic for the betterment of patient care and brain health monitoring. C2N’s Precivity tests are innovative prescription-only blood tests intended for use in individuals experiencing cognitive impairment. The Precivity tests help physicians better determine the presence or absence of amyloid plaques in the brain, a hallmark sign of Alzheimer’s Disease. C2N currently operates two state-of-the-art laboratory facilities in St. Louis, Missouri. This position is onsite at one of C2N's facilities in St. Louis.
C2N is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, national origin, disability status, veteran status, marital or parental status, pregnancy, citizenship status, sexual orientation, gender identity and/or expression or any other characteristic protected by law.
Responsibilities
Develop, implement and routinely perform biological sample preparation workflows and LC-MS/MS analyses for quantifying and characterizing blood-based biomarkers of neurodegeneration.
Duties
- Convert laboratory developed tests into analytically validated (CLIA, FDA, ISO) in vitro diagnostic biomarker tests used for research, clinical trials, and clinical diagnosis of neurodegenerative disorders.
- Draft, implement and continuously evaluate sample preparation and analysis protocols/SOPs for detecting, identifying, and quantifying peptides/proteins and other biomolecules in human blood samples.
- Maintain and operate LC, LC-MS, automated liquid handlers, LIMS, and related laboratory equipment
- Supervise medical technologists and routinely prepare and perform sample analyses for clients
- Comply with established laboratory regulations, standards, policies, protocols, processes, procedures, and plans. Adapt to changes in these regulations and standards as they are announced
- Assist with sample accessioning, quality control, process improvement, equipment maintenance, proficiency/competency training standards and schedules
- Report to Sr Director of Clinical Chemistry and Commercial Assays
Skills
- Training and experience with LC, LC-MS/MS based biomolecule analysis
- Training and experience with operating and maintaining high resolution MS instrumentation
- Highly motivated, achievement-oriented, attention to detail, well organized, team player with good oral and written communication skills
- Ability to troubleshoot and problem solve sample preparation and analytical strategies with laboratory members
- Ability to manage, conduct, and supervise multiple analytical projects
- Experience with routine (Word, Excel, Power Point), LC, and MS specific software applications
Education/Training
- PhD in Analytical Chemistry, Biochemistry, Laboratory Medicine, Mass Spectrometry, or related technical field
- Minimum experience: 5+ years’ experience in a CLIA-accredited laboratory conducting LC or LC-MS in vitro diagnostics testing
Job Type: Full-time
Pay: $105,000.00 - $130,000.00 per year
Benefits:
- 401(k)
- Health insurance
- Paid time off
- Vision insurance
Schedule:
Ability to commute/relocate:
- St. Louis, MO 63110: Reliably commute or planning to relocate before starting work (Preferred)
Education:
Work Location: In person