The laboratory of Dr. Xue Han is seeking a Research Technician to provide technical support for research projects in Cancer Immunology and Immunotherapy as directed.
The main research interests of the Han Lab are to 1) study new mechanisms of immune escape in solid tumors and hematologic malignancies; 2) identify novel immunomodulatory pathways and their applications to treat cancer, inflammation, and autoimmune diseases; 3) understand the mechanisms of immune-related adverse events caused by cancer immunotherapy. Her current research is focusing on PD-1H (VISTA), a newly identified immune check point molecule, to study the mechanisms of how this pathway modulates anti-cancer immunity and controls autoimmune responses and to develop new therapeutic methods in mouse cancer and immune-related disease models. She is also putting big efforts in translating her studies into clinic.
Job Duties:
Perform complex laboratory experiments using advanced genetic and immunological technologies (for example, single cell sequencing, high dimensional imaging, cloning, molecular biology, protein expression and purification, immunohistochemistry, Western blot, tissue culture, ELISA, PCR and flow cytometry)
Collect, sort, and process tissue and blood samples from cancer patients as well as from preclinical animal models
Assist with routine animal husbandry
Consolidate research data for the preparation of research reports, publications and grant applications written by PI
Research current scientific literature on specified topics
Assist with ordering, stocking, and maintenance of research supplies
Calibrate various laboratory equipment and operate microscopes, centrifuges and other laboratory equipment
Perform other duties as assigned
Education
Experience
Knowledge of genetic and immunological technologies, single cell sequencing, high dimensional imaging, cloning, molecular biology, immunohistochemistry, Western blot, tissue culture, ELISA, PCR and flow cytometry is preferred.
Experience working with mouse models preferred.
While previous experience in the afore-mentioned methodologies is desirable, the ideal candidate will be highly motivated and have a desire to learn new techniques and knowledge.
Requires successful completion of a background check; qualified candidates may be asked to complete a pre-employment physical, including a drug screen.
Function: Research and Scholarship
Sub Function: Research
Career Band: Individual Contributor - Technical
Career Level: T3
The OSUCCC – James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities. The Pelotonia Institute for Immuno-Oncology (PIIO) is a comprehensive bench-to-bedside research initiative focused on harnessing the body’s immune system to fight cancer at all levels —from prevention to treatment and survivorship.
Salary range for this position: $17.31-$22.77 per hour
Regular 40 First Shift